Cancer metabolism and carcinogenesis
Emory University · Georgia Institute of Technology · +1 more institution
Abstract
Metabolic reprogramming is an emerging hallmark of cancer cells, enabling them to meet increased nutrient and energy demands while withstanding the challenging microenvironment. Cancer cells can switch their metabolic pathways, allowing them to adapt to different microenvironments and therapeutic interventions. This refers to metabolic heterogeneity, in which different cell populations use different metabolic pathways to sustain their survival and proliferation and impact their response to conventional cancer therapies. Thus, targeting cancer metabolic heterogeneity represents an innovative therapeutic avenue with the potential to overcome treatment resistance and improve therapeutic outcomes. This review…
Citation impact
- FWCI
- 30.83
- Percentile
- 100%
- References
- 158
Authors
4- JYJianqiang YangCorresponding
Emory University
- CSChloe Shay
Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering
- NFNabil F. Saba
Emory University
- YTYong Teng
Georgia Institute of Technology, Emory University, The Wallace H. Coulter Department of Biomedical Engineering
Topics & keywords
- Cancer
- Cancer cell
- Medicine
- Carcinogenesis
- Metabolic pathway
- Bioinformatics
- Cell metabolism
- Tumor microenvironment