Mitochondria in disease: changes in shapes and dynamics

Mitochondrial structure often determines the function of these highly dynamic, multifunctional, eukaryotic organelles, which are essential for maintaining cellular health. The dynamic nature of mitochondria is apparent in descriptions of different mitochondrial shapes [e.g., donuts, megamitochondria (MGs), and nanotunnels] and crista dynamics. This review explores the significance of dynamic alterations in mitochondrial morphology and regulators of mitochondrial and cristae shape. We focus on studies across tissue types and also describe new microscopy techniques for detecting mitochondrial morphologies both in vivo and in vitro that can improve understanding of mitochondrial structure. We highlight the…

• HH
  Howard Hughes Medical Institute
• BW
  Burroughs Wellcome Fund

  Awards: 5R25HL106365-12, 1021868.01, DK020593
• SV
  Silicon Valley Community Foundation

  Awards: 1022604, GT15655
• BS
  Bristol-Myers Squibb
• VU
  Vanderbilt University
• NI
  National Institutes of Health

  Awards: DK020593, R01HL144941, R03HL155041, R21TW012635, 5R25HL106365-12, R01HL165729, R01HL157584, R01GM151746, R01HL147818, R01DK135764
• VD
  Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center

  Award: 2022-253529