Targeting the Warburg Effect in Cancer: Where Do We Stand?
Universitat de Vic - Universitat Central de Catalunya · Universitat Autònoma de Barcelona · +2 more institutions
Abstract
The Warburg effect, characterized by the preferential conversion of glucose to lactate even in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of cancer cells and has emerged as a promising therapeutic target for cancer therapy. Elevated lactate levels and acidic pH within the tumor microenvironment (TME) resulting from glycolytic profoundly impact various cellular populations, including macrophage reprogramming and impairment of T-cell functionality. Altogether, the Warburg effect has been shown to promote tumor progression and immunosuppression through multiple mechanisms. This review provides an overview of the current understanding of the Warburg effect in cancer and…
Citation impact
- FWCI
- 48.68
- Percentile
- 100%
- References
- 147
Authors
3- IBIgnasi BarbaCorresponding
Universitat de Vic - Universitat Central de Catalunya, Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red de Cáncer
- LCLaura Carrillo-Bosch
Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red de Cáncer
- JSJoan Seoane
Institució Catalana de Recerca i Estudis Avançats, Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red de Cáncer
Topics & keywords
- Warburg effect
- Tumor microenvironment
- Glycolysis
- Cancer cell
- Cancer
- Reprogramming
- Immune system
- Anaerobic glycolysis
- Good health and well-being