Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
National Clinical Research Center for Digestive Diseases · First Affiliated Hospital Zhejiang University · +2 more institutions
Abstract
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The Notch receptor and its ligands are transmembrane proteins containing epidermal growth factor-like repeat sequences, typically necessitating receptor-ligand interaction to initiate classical Notch signaling transduction. Accumulating evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer types. Dysregulation of this pathway promotes epithelial-mesenchymal transition and angiogenesis in malignancies, closely linked to cancer proliferation, invasion, and metastasis.…
Citation impact
- FWCI
- 69.59
- Percentile
- 100%
- References
- 581
Authors
10- QSQingmiao ShiCorresponding
National Clinical Research Center for Digestive Diseases, First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- CXChen Xue
National Clinical Research Center for Digestive Diseases, First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- YZYifan Zeng
National Clinical Research Center for Digestive Diseases, First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- XYXin Yuan
National Clinical Research Center for Digestive Diseases, First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- QCQingfei Chu
National Clinical Research Center for Digestive Diseases, First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
Topics & keywords
- Notch signaling pathway
- Signal transduction
- Computational biology
- Biology
- Cancer
- Cancer research
- Bioinformatics
- Cell biology