The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer

Aberrant activation of the PI3K/Akt pathway commonly occurs in cancers and correlates with multiple aspects of malignant progression. In particular, recent evidence suggests that the PI3K/Akt signaling plays a fundamental role in promoting the so-called aerobic glycolysis or Warburg effect, by phosphorylating different nutrient transporters and metabolic enzymes, such as GLUT1, HK2, PFKB3/4 and PKM2, and by regulating various molecular networks and proteins, including mTORC1, GSK3, FOXO transcription factors, MYC and HIF-1α. This leads to a profound reprogramming of cancer metabolism, also impacting on pentose phosphate pathway, mitochondrial oxidative phosphorylation, de novo lipid synthesis and redox…

• UD
  Università degli Studi di Milano
• MD
  Ministero dell’Istruzione, dell’Università e della Ricerca

  Award: 2015B7M39T_004
• FU
  Fondazione Umberto Veronesi