Mitochondrial quality control in human health and disease

Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable in vital life processes such as cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, a sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key processes like mitochondrial biogenesis, mitochondrial dynamics, and mitophagy, which have garnered increasing attention from researchers to unveil their specific molecular mechanisms. In this review, we present a comprehensive summary of…

• NN
  National Natural Science Foundation of China

  Awards: 81800343, 8210082163, 81770095
• NS
  Natural Science Foundation of Hubei Province

  Award: 2020CFA027
• SF
  Science Fund for Creative Research Groups

  Award: 2020CFA027
• JU
  Jilin University
• FF
  Foundation for Innovative Research Groups of Hubei Province of China

  Award: 2020CFA027
• FR
  Fundamental Research Funds for the Central Universities

  Award: 2042021kf0081
• FH
  First Hospital of Jilin University