Mitochondrial Structure and Function in Human Heart Failure

Despite clinical and scientific advancements, heart failure is the major cause of morbidity and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the development and progression of heart failure. Although inflammation is crucial to reparative healing following acute cardiomyocyte injury, chronic inflammation damages the heart, impairs function, and decreases cardiac output. Mitochondria, which comprise one third of cardiomyocyte volume, may prove a potential therapeutic target for heart failure. Known primarily for energy production, mitochondria are also involved in other processes including calcium homeostasis and the regulation of cellular apoptosis. Mitochondrial function…

• SV
  Silicon Valley Community Foundation
• AH
  American Heart Association

  Award: 828058
• BS
  Barth Syndrome Foundation
• VU
  Vanderbilt University
• NI
  National Institutes of Health

  Awards: DK020593, R01HL144941, 5R25HL106365-12, R01HL165729, R01GM151746, R01HL147818