Mitochondria- and ER-associated actin are required for mitochondrial fusion
Université du Québec à Montréal · Université du Québec · +3 more institutions
Abstract
Mitochondria are crucial for cellular metabolism and signalling. Mitochondrial activity is modulated by mitochondrial fission and fusion, which are required to properly balance metabolic functions, transfer material between mitochondria, and remove defective mitochondria. Mitochondrial fission occurs at mitochondria-endoplasmic reticulum (ER) contact sites, and requires the formation of actin filaments that drive mitochondrial constriction and the recruitment of the fission protein DRP1. The role of actin in mitochondrial fusion remains entirely unexplored. Here we show that preventing actin polymerisation on either mitochondria or the ER disrupts both fission and fusion. We show that fusion but not fission is…
Citation impact
- FWCI
- 32.72
- Percentile
- 100%
- References
- 50
Authors
5- PGPriya GattiCorresponding
Université du Québec à Montréal, Université du Québec, Université du Québec à Trois-Rivières
- CRCara R. Schiavon
University of California San Diego
- JCJulien Cicero
University of California San Diego
- UMUri Manor
University of California San Diego
- MGMarc Germain
Université du Québec à Montréal, The Quebec Population Health Research Network, Université du Québec, Université du Québec à Trois-Rivières
Topics & keywords
- Mitochondrial fission
- Cell biology
- Mitochondrion
- MFN2
- mitochondrial fusion
- Actin
- Formins
- Biology
Funding
- NSNational Science Foundation
- WFWaitt Foundation
- NINational Institutes of HealthAwards: CA014195, P30AG068635
- NSNatural Sciences and Engineering Research Council of CanadaAward: RGPIN-2019-07197
- FDFonds de Recherche du Québec - Santé
- NINational Institute on AgingAwards: CA014195, P30AG068635
- NCNational Cancer InstituteAward: CA014195
- NINational Institute on Deafness and Other Communication DisordersAwards: DC021075, R01 DC021075