reviewnpj Digital MedicineJan 17, 2025GOLD OA

Survey and perspective on verification, validation, and uncertainty quantification of digital twins for precision medicine

Decision Systems (United States) · Massachusetts Institute of Technology · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Digital twins in precision medicine provide tailored health recommendations by simulating patient-specific trajectories and interventions. We examine the critical role of Verification, Validation, and Uncertainty Quantification (VVUQ) for digital twins in ensuring safety and efficacy, with examples in cardiology and oncology. We highlight challenges and opportunities for developing personalized trial methodologies, validation metrics, and standardizing VVUQ processes. VVUQ frameworks are essential for integrating digital twins into clinical practice.

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