reviewInternational Journal of Molecular SciencesJan 23, 2025GOLD OA

Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential

CTCheryl TungFVFahimeh VarzidehEFEmanuele FarroniPMPasquale MoneUKUrna Kansakar

Albert Einstein College of Medicine · Casa di cura Pierangeli

PubMed
Indexed incrossrefpubmed

Abstract

Mitochondria serve an essential metabolic and energetic role in cellular activity, and their dysfunction has been implicated in a wide range of disorders, including cardiovascular conditions, neurodegenerative disorders, and metabolic syndromes. Mitochondria-targeted therapies, such as Elamipretide (SS-31, MTP-131, Bendavia), have consequently emerged as a topic of scientific and clinical interest. Elamipretide has a unique structure allowing for uptake in a variety of cell types and highly selective mitochondrial targeting. This mitochondria-targeting tetrapeptide selectively binds cardiolipin (CL), a lipid found in the inner mitochondrial membrane, thus stabilizing mitochondrial cristae structure, reducing…

Citation impact

70
total citations
FWCI
43.14
Percentile
100%
References
59
Citations per year

Authors

7

Topics & keywords

Topics
Keywords
  • Mitochondrion
  • Cardiolipin
  • Oxidative stress
  • Neurodegeneration
  • Bioenergetics
  • Pharmacology
  • Biology
  • Oxidative phosphorylation
UN Sustainable Development Goals
  • Good health and well-being
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