Hepatocellular carcinoma: signaling pathways and therapeutic advances
Shanghai Jiao Tong University · Renji Hospital · +7 more institutions
Abstract
Liver cancer represents a major global health concern, with projections indicating that the number of new cases could surpass 1 million annually by 2025. Hepatocellular carcinoma (HCC) constitutes around 90% of liver cancer cases and is primarily linked to factors incluidng aflatoxin, hepatitis B (HBV) and C (HCV), and metabolic disorders. There are no obvious symptoms in the early stage of HCC, which often leads to delays in diagnosis. Therefore, HCC patients usually present with tumors in advanced and incurable stages. Several signaling pathways are dis-regulated in HCC and cause uncontrolled cell propagation, metastasis, and recurrence of HCC. Beyond the frequently altered and therapeutically targeted…
Citation impact
- FWCI
- 263.50
- Percentile
- 100%
- References
- 714
Authors
10- JZJiaojiao Zheng
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute
- SWSiying Wang
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute
- LXLei Xia
Shanghai Jiao Tong University, Renji Hospital
- SZSun Zhen
Shanghai Jiao Tong University, Renji Hospital, Shanghai Cancer Institute
- KMKui Ming Chan
City University of Hong Kong
Topics & keywords
- Hepatocellular carcinoma
- Medicine
- Cancer research
- Metastasis
- Immunotherapy
- Cancer
- Signal transduction
- Tyrosine kinase
- Good health and well-being