Integrative metabolism in MASLD and MASH: Pathophysiology and emerging mechanisms
McMaster University Medical Centre · The University of Melbourne
Abstract
The liver acts as a central metabolic hub, integrating signals from the gastrointestinal tract and adipose tissue to regulate carbohydrate, lipid, and amino acid metabolism. Gut-derived metabolites, such as acetate and ethanol, and non-esterified fatty acids from white adipose tissue influence hepatic processes, which rely on mitochondrial function to maintain systemic energy balance. Metabolic dysregulation caused by obesity, insulin resistance, and type 2 diabetes disrupts these pathways, leading to metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH). In this review, we explore the metabolic fluxes within the gut-adipose tissue-liver axis, focusing on the pivotal role…
Citation impact
- FWCI
- 129.98
- Percentile
- 100%
- References
- 142
Authors
4Topics & keywords
- Pathophysiology
- Medicine
- Internal medicine
- Zero hunger