SLC7A11 is an unconventional H+ transporter in lysosomes

Zhou, Nan; Chen, Jingzhi; Hu, Meiqin; Wen, Na; Cai, Weijie; Li, Ping; Zhao, Liding; Meng, Yaping; Dongdong, Zhao; Yang, Xiaotong; Liu, Siyu; Huang, Fangqian; Zhao, Cheng; Feng, Xinghua; Jiang, Zikai; Xie, Enjun; Pan, Hongxu; Cen, Zhidong; Chen, Xinhui; Luo, Wei; Tang, Beisha; Min, Junxia; Wang, Fudi; Yang, Junsheng; Xu, Haoxing

doi:10.1016/j.cell.2025.04.004

articleCellApr 23, 2025HYBRID OA

SLC7A11 is an unconventional H+ transporter in lysosomes

NZNan Zhou JCJingzhi Chen MHMeiqin Hu NWNa Wen WCWeijie Cai

Zhejiang University of Technology · Second Affiliated Hospital of Zhejiang University · +6 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Transport conduit that is integral to lysosomal flux of protonatable metabolites to regulate lysosome function, ferroptosis, and Parkinson's disease (PD) pathology.

Citation impact

total citations

FWCI: 37.75
Percentile: 100%
References: 94

Citations per year

Authors

NZ
Nan ZhouCorresponding
Zhejiang University of Technology
JC
Jingzhi Chen
Zhejiang University of Technology
MH
Meiqin Hu
Second Affiliated Hospital of Zhejiang University
NW
Na Wen
Zhejiang University of Technology
WC
Weijie Cai
Second Affiliated Hospital of Zhejiang University

Topics & keywords

Topics

Amino Acid Enzymes and Metabolism100%
Calcium signaling and nucleotide metabolism100%
Neonatal Health and Biochemistry100%

Keywords

Biology
Transporter
Cell biology
Biochemistry
Gene

No related works found for this paper.

Funding

IR
Innovative Research Group Project of the National Natural Science Foundation of China
NN
National Natural Science Foundation of China
Awards: 31930057, 92354306, 32421001, 32330047, 31970689
KT
Key Technologies Research and Development Program
Award: 2022YFE0210100
NK
National Key Research and Development Program of China