The gut microbiota and host immunity synergistically orchestrate colonization resistance

Colonization resistance is a fundamental host defense mechanism that relies on the synergistic interaction between the gut microbiota and the host immune system to prevent enteric pathogen colonization and infection. This review synthesizes current knowledge of the multifaceted mechanisms governing colonization resistance against intestinal pathogens. We examine how commensal microbes directly suppress pathogens through niche and nutrient competition, contact-dependent inhibition, and the production of antimicrobial compounds and metabolites. From the host perspective, we outline the essential roles of gut barriers, innate and adaptive immunity, and antimicrobial peptides in maintaining microbiota homeostasis…

• NN
  National Natural Science Foundation of China

  Award: 32530036, 32170872, 82122030
• NK
  National Key Research and Development Program of China

  Award: 2023YFC2306202