articleNature CommunicationsJan 7, 2026GOLD OA

Associations between preservative food additives and type 2 diabetes incidence in the NutriNet-Santé prospective cohort

Conservatoire National des Arts et Métiers · Inserm · +17 more institutions

PubMed
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Abstract

Experimental studies suggested potential adverse effects of preservative food additives, but epidemiological data are lacking. We aim to investigate associations between exposure to these compounds and type 2 diabetes incidence in the NutriNet-Santé prospective cohort (n = 108,723; 79.2%women; mean age=42.5 (SD = 14.6); France, 2009-2023). Dietary intakes are assessed using repeated 24h-dietary records. Exposure is evaluated through multiple composition databases and ad-hoc laboratory assays in food matrices. Associations between cumulative exposures to preservatives and diabetes incidence are characterised using multi-adjusted Cox models. The sum of total preservatives encompasses 58 substances. Among those,…

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5
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FWCI
65.90
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100%
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Authors

21

Topics & keywords

Keywords
  • Incidence (geometry)
  • Preservative
  • Type 2 diabetes
  • Prospective cohort study
  • Cohort
  • Population
  • Cohort study
  • Diabetes mellitus
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