Integrative Approaches to Uncover the Therapeutic Action of Huaiqihuang in Myocarditis: Network Pharmacology, Molecular Docking, and Molecular Dynamics

Myocarditis (MC) is an inflammatory cardiomyopathy with high morbidity and mortality. Current treatment options for MC have limitations and side effects, necessitating the exploration of new therapies. Traditional Chinese Medicine (TCM), particularly Huaiqihuang Granules (HQH), has shown promise due to its anti-inflammatory, antioxidative, and anti-apoptotic properties. However, the application in cardiovascular diseases remains underexplored.

We employed network pharmacology, molecular docking, and Molecular Dynamics (MD) simulations to evaluate HQH's effects on MC. This involved identifying bioactive components and therapeutic targets, conducting enrichment analyses, and performing molecular docking and MD simulations to validate the interactions between HQH components and MC-related targets.