Aflatoxins and Human Health: Global Exposure, Disease Burden, and One Health Strategies
National Cancer Institute · All India Institute of Medical Sciences · +2 more institutions
Abstract
, are the most detrimental for human health. In this review, we discuss the sources of exposure and geographic distribution. The prevalence of aflatoxin-albumin/lysine adduct detection in humans varies dramatically across the world, from 0% reported in two European studies to up to 100% reported in studies from parts of Africa and Asia. We also summarize the disease outcomes that aflatoxins are associated with in humans. We focus particularly on cancer outcomes, which aflatoxins can cause through mutagenic DNA adducts, oxidative stress, mitochondrial dysfunction, immune effects, and epigenetic changes. Synergy with hepatitis B virus and potentially with other mycotoxins can also increase risk. Minimization of…
Citation impact
- FWCI
- 63.43
- Percentile
- 100%
- References
- 0
Authors
4- JKJill KoshiolCorresponding
National Cancer Institute
- AYAmit Yadav
All India Institute of Medical Sciences
- JDJohn D. Groopman
Johns Hopkins University
- UDUsha Dutta
Post Graduate Institute of Medical Education and Research
Topics & keywords
- Aflatoxin
- Mycotoxin
- Disease
- Public health
- Biomonitoring
- Risk assessment
- Human health
- Global health